Validation of an UV-Visible spectrophotometry assay method for the determination of chlorpheniramine maleate tablets without prior extraction

Development and Validation of an Uv Spectrophotometric Method for the Determination of Aliskiren in Tablets

For determination of aliskiren in commercial samples, an analytical UV spectrophotometric method was developed and validate according to ICH guideline. The method was linear in the range between 40 and 100 μg mL (r = 0.9997, n = 7) and exhibited suitable specificity, accuracy, precision, and robustness. It is simple, it has low cost, and it has low use polluting reagents. Therefore, the propose...

Validated Determination of Meloxicam in Tablets by Using UV Spectrophotometry

Meloxicam (MEL) (4-hydroxy-2-methyl-N-(5-methyl-2-thiazoly)-2H1,2-benzo-thiazine-3-carboxamide-1,1dioxide) (C14H13N3O4S2) (Figure 1) is a non-steroidal anti-inflammatory drug (NSAID) 1,2. MEL is a novel NSAIDs with a favorable COX-2 (cyclooxgenase-2): COX-1 (cyclooxgenase-1) selectivity has also been shown to have potent anti-inflammatory effects 3,4. Because of very low solubility of MEL in ac...

Basic UV/Visible Spectrophotometry

Determination of Triiodide Ion Concentration Using UV-Visible Spectrophotometry†

The concentration of iodine species can be measured using several different analysis methods. One of the most wellknown methods involves iodine titration with a thiosulfate solution. Total iodine can be analyzed using spectrometry, such as inductively coupled plasma-atomic emission spectrometry (ICP-AES), atomic absorption spectrometry (AAS) and inductively coupled plasma-mass spectrometry (ICP...

Development and Validation of an UV-Derivative Spectrophotometric Method for Determination of Glimepiride in Tablets

A glimepirida é um fármaco antidiabético oral usado no tratamento da diabetes tipo 2. Este trabalho propôs o desenvolvimento e validação de um método por espectrofotometria derivada na região do ultravioleta para determinação de glimepirida em comprimidos. A quantificação de glimepirida em solução de NaOH 5×10 mol L foi realizada usando um intervalo de 8 nm entre 220 a 300 nm. Os valores de amp...